Effects of pioglitazone injection into hippocampal CA1 area on spatial learning and memory deficits in rats
| Author | Amir Farshchi | en |
| Author | Golbarg Ghiasi | en |
| Author | Gholam-Reza Bahrami | en |
| Author | Ali Pourmotabbed | en |
| Author | Sayyed-Ershad Nedaee | en |
| Issued Date | 2011-03-20 | en |
| Abstract | Background: Pioglitazone from thiazolidinediones generation, represent a new antidiabetic drugs that have been introduced in the world recently. Thiazolidinediones can improve insulin resistance by activating the nuclear peroxoxisome proliferator activated receptor-γ (PPAR-γ) and increasing insulin sensitivity in their receptors. Insulin and its receptors are found in specific areas of CNS with a variety of region-specific functions. The effects of insulin in CNS are different from its direct glucose regulation in the periphery. Hippocampus and cerebral cortex distributed insulin/insulin receptor have been shown to be involved in brain cognitive functions. In the present study, the effect of pioglitazone microinjection into CA1 region of rat hippocampus using Morris water maze performance has been investigated. | en |
| DOI | https://doi.org/ | en |
| Keyword | pioglitazone | en |
| Keyword | hippocampus | en |
| Keyword | spatial learning and memory | en |
| Keyword | morris water maze | en |
| Keyword | rat | en |
| Publisher | Brieflands | en |
| Title | Effects of pioglitazone injection into hippocampal CA1 area on spatial learning and memory deficits in rats | en |
| Type | Research Article | en |
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