Examining the Cardioprotective Effects of Aerobic Exercise Combined with Crocin or Berberine on Methamphetamine-Induced Heart Damage in Female Rats
| Author | Sayed Javad Ziaolhagh | en |
| Author | Somayeh Rajabi | en |
| Author | Zahra Nosrati | en |
| Orcid | Somayeh Rajabi [0009-0002-1548-3837] | en |
| Orcid | Zahra Nosrati [0009-0001-6644-3045] | en |
| Issued Date | 2024-09-30 | en |
| Abstract | Background: While the harmful effects of methamphetamine abuse on the heart are well-known, the solutions to deal with these damages are not well-known. Objectives: This study aimed to investigate whether aerobic exercise combined with supplements such as Crocin and Berberine can potentially protect against methamphetamine-induced changes in the heart tissue of female rats. Materials and Methods: Forty-two female rats were randomly assigned into seven groups (n = 6). The groups included healthy control, methamphetamine, methamphetamine + exercise, methamphetamine + Crocin, methamphetamine + Berberine, methamphetamine + exercise + Crocin, and methamphetamine + exercise + Berberine group. Methamphetamine (10 mg/kg) was injected intraperitoneally over five days. The animals were administered Crocin via intraperitoneal injection at 40 mg/kg during a four-week withdrawal period. At the same time, Berberine was dissolved in drinking water at 100 mg/kg concentration. The aerobic training consisted of running at 25 m/min for 30 minutes. A light microscope was used to observe the structural changes. Data analysis was performed using non-parametric Kruskal-Wallis and Mann-Whitney U tests by SPSS 26, with a significance level of 5%. Results: The results of the study indicate that methamphetamine use causes hyperemia, inflammation, and histopathological damage in the heart cells and tissue (P = 0.001). The combination of exercise with Crocin significantly eliminated methamphetamine-induced heart tissue damage (P = 0.001) and improved cardio-respiratory endurance compared to control (P = 0.004) and methamphetamine (P = 0.01) groups. The combination of aerobic exercise with Berberine removed methamphetamine-induced heart cell damage (P = 0.001), and improved cardio-respiratory endurance compared to control (P = 0.024) and methamphetamine (P = 0.05) groups. In addition, all intervention groups showed a significant reduction in hyperemia and inflammation compared to the methamphetamine group (P = 0.001). Conclusions: A combination of exercise with either Crocin or Berberine supplements demonstrated potential benefits in mitigating some of the harmful structural effects of methamphetamine and improving cardio-respiratory endurance. | en |
| DOI | https://doi.org/10.5812/ijhrba-147435 | en |
| URI | https://brieflands.com/journals/ijhrba/articles/147435 | en |
| Keyword | Exercise | en |
| Keyword | Berberine | en |
| Keyword | Crocin | en |
| Keyword | Heart | en |
| Keyword | Methamphetamine | en |
| Publisher | Brieflands | en |
| Title | Examining the Cardioprotective Effects of Aerobic Exercise Combined with Crocin or Berberine on Methamphetamine-Induced Heart Damage in Female Rats | en |
| Type | Research Article | en |