Thyroid Function in the Time of COVID-19: A Systematic Review of Disease Progression and Vaccination Effect
| Author | Maryam Zarkesh | en |
| Author | Maryam Sanoie | en |
| Author | Shabnam Heydarzadeh | en |
| Author | Raziyeh Abooshahab | en |
| Author | Afsoon Daneshafrooz | en |
| Author | Farhad Hosseinpanah | en |
| Author | Mehdi Hedayati | en |
| Orcid | Farhad Hosseinpanah [0000-0001-5235-9451] | en |
| Orcid | Mehdi Hedayati [0000-0001-5816-775X] | en |
| Issued Date | 2024-07-31 | en |
| Abstract | Objectives: This systematic review sought to address three key questions: (1) what differences in abnormal thyroid function test results are observed between COVID-19 patients and healthy individuals? (2) How does the severity of COVID-19 infection influence the development of thyroid dysfunction? (3) What impact do COVID-19 vaccines have on thyroid function and autoimmune processes? Methods: A literature search was conducted in PubMed, Web of Science, and Scopus from December 2019 to April 2023 to identify studies on thyroid dysfunction in COVID-19 patients without pre-existing thyroid conditions. The search focused on observational and case-control studies. Results: The literature search yielded 329 reports, from which duplicates and unrelated publications were excluded. Ultimately, 21 studies met the inclusion criteria and were selected for review. A second literature search yielded 605 reports, from which 5 studies were selected for inclusion in the systematic review. Conclusions: The findings suggest that SARS-CoV-2 infection can induce transient and reversible thyroid dysfunction, possibly through direct viral effects on the thyroid gland or via indirect immune-mediated mechanisms. Clinicians should be mindful of the potential, albeit rare, thyroid-related adverse effects of COVID-19 vaccines and monitor thyroid function, particularly in high-risk individuals. | en |
| DOI | https://doi.org/10.5812/ijem-146857 | en |
| Keyword | Thyroid Hormones | en |
| Keyword | Thyroid Diseases | en |
| Keyword | SARS-CoV-2 Virus | en |
| Keyword | Vaccines | en |
| Publisher | Brieflands | en |
| Title | Thyroid Function in the Time of COVID-19: A Systematic Review of Disease Progression and Vaccination Effect | en |
| Type | Systematic Review | en |
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