Investigating the Relationship Between Perineural Invasion and Tumor Stage in Patients with Colorectal Adenocarcinoma in Shahid Sadoughi Hospital, Yazd, 2014 - 2022

Abstract

Background: The incidence of colorectal cancer in Iran has been reported at seven cases per 100,000 people, making it the fourth most prevalent cancer in the country. Evaluating the prognosis of patients with colorectal cancer can be instrumental in predicting clinical outcomes. Objectives: This study aimed to investigate the relationship between perineural invasion (PNI) and tumor stage in patients with adenocarcinoma. Methods: This descriptive-analytical, cross-sectional study used the census sampling method, including all samples sent to the pathology department of Shahid Sadoughi Hospital in Yazd from 2012 to 2020. The study included samples from 169 patients diagnosed with colorectal adenocarcinoma. Demographic and clinicopathological data, such as tumor grade, stage, and recurrence status, were collected from patient records. Data analysis was conducted using SPSS version 22, with a significance level set at P < 0.05. Results: The average age of patients was 58.8 ± 17.8 years, with 89 males (52.7%) and 80 females (47.3%). The findings demonstrated that PNI had a statistically significant relationship with age (P = 0.047) and tumor stage (P = 0.014). However, no statistically significant relationship was observed with other variables, such as sex, recurrence, site of recurrence, grade, tumor location, and size (P > 0.05). Conclusions: This study found a significant association between PNI and both age and tumor stage, suggesting that tumor stage serves as an independent poor prognostic factor for PNI status in colorectal cancer.