Effect of Intravenous Patient Controlled Ketamine Analgesiaon Postoperative Pain in Opium Abusers
| Author | Mastane Dahi-Taleghani | en |
| Author | Benjamin Fazli | en |
| Author | Mahshid Ghasemi | en |
| Author | Maryam Vosoughian | en |
| Author | Ali Dabbagh | en |
| Orcid | Ali Dabbagh [0000-0003-4344-8131] | en |
| Issued Date | 2014-02-01 | en |
| Abstract | Background: Acutepostoperative pain is among the worst experience that patient scan undergo, and many analgesics have been used to suppress it; especially in chronic opium abusers. Ketamine is an N-methyl-D-aspartate antagonist analgesic, having both anesthetic and analgesic properties, which are not affected to the same extent in chronic opium abusers. Objectives: In this study, we assessed the analgesic effects of ketamine added to morphine as a patient-controlled analgesia method for acute pain management, compared with a placebo, inchronic maleopium abusers. Patients and Methods: After institutional review board approval for ethical considerations, a randomized double-blinded placebo controlled clinical trial was conducted. A total of 140 male patients aged 18-65 years, undergoing orthopedic surgery, were entered into the study after matching inclusion and exclusion criteria. All patients received the same anesthesia method; while the first group received ketamine (1mg/mL) and morphine (0.5 mg/mL) as a patient-controlled analgesia (70 patients), the second group received morphine (0.5 mg/mL) plus normal saline (70 patients). P value less than 0.05 was considered statistically significant. Results: The ketamine and morphine group of patients experienced less postoperative pain and required less postoperative rescue analgesia. However, the unwanted postoperative side effects were nearly the same; although increased levels of postoperative nausea and vomiting were observed in the ketamine and morphine group Conclusions: This study demonstrated improved analgesic effects after using intravenous patient controlled analgesia with ketamine on postoperative pain in opium abusers. | en |
| DOI | https://doi.org/10.5812/aapm.14129 | en |
| URI | https://brieflands.com/journals/aapm/articles/17369 | en |
| Keyword | Ketamine | en |
| Keyword | Acute Pain | en |
| Keyword | Opium | en |
| Keyword | Drug Users | en |
| Publisher | Brieflands | en |
| Title | Effect of Intravenous Patient Controlled Ketamine Analgesiaon Postoperative Pain in Opium Abusers | en |
| Type | Research Article | en |
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