Antinociceptive and anti-inflammatory, and acute toxicity effects of Asparagus persicus essential oil in male mice
| Author | Ali reza fallahzadeh | en |
| Author | saeed mohammadi | en |
| Issued Date | 2021-08-31 | en |
| Abstract | Introduction: In Iranian traditional medicine, Asparagus persicus has been used for treating rheumatic pain and inflammation. The aim of this study was to evaluate the analgesic and anti-inflammatory as well as acute toxicity effects of Asparagus persicus root essential oil (APEO) in male mice. Materials and Methods: Male adult mice were used. In pain assessment tests (writhing, tail-flick, and formalin tests), animals divided to the six groups: control/vehicle (Tween 80+distilled water), three groups treated with the APEO (100, 200, and 400 mg/kg, gavage/oral treating), morphine (i.p.), and naloxone (i.p.) plus APEO (400 mg/kg). Moreover, inflammation test (xylene and carrageenan tests), animals divided to five groups: control, three groups of APEO (orally), and dexamethasone (i.p.). For toxicity tests, the animals were divided to the six groups. Results: Results showed that APEO at a dose of 400 mg/kg in writhing and tailflick tests induced an antinociceptive effect as compared with the control (P | en |
| DOI | https://doi.org/ | en |
| Keyword | Anti-Inflammatory Agents | en |
| Keyword | Analgesics | en |
| Keyword | Asparagus Plant | en |
| Keyword | Toxicity | en |
| Keyword | عوامل ضد التهاب | en |
| Keyword | داروهای ضد درد | en |
| Keyword | گیاه مارچوبه | en |
| Keyword | سمیت | en |
| Publisher | Brieflands | en |
| Title | Antinociceptive and anti-inflammatory, and acute toxicity effects of Asparagus persicus essential oil in male mice | en |
| Type | Research Article | en |