Endothelium-dependent effect of Amaranthus caudatus feeding on contractile properties of thoracic aorta from diabetic rats
| Author | Mehrdad Roghani | en |
| Author | Tourandokht BalochNezhadMojarad | en |
| Author | Farshad RoghaniDehkordi | en |
| Orcid | Mehrdad Roghani [0000-0002-9209-8484] | en |
| Issued Date | 2011-09-30 | en |
| Abstract | Introduction: Diabetes mellitus is accompanied with higher incidence of cardiovascular disorders. There is some evidence of antidiabetic and vascular function-improving potential of Amaranthus caudatus (AC). Endothelium-dependent effects of oral administration of AC for 8 weeks on contractile and relaxatory response of thoracic aorta from diabetic rats were investigated. Materials and Methods: Wistar rats were divided into control, AC-treated control, diabetic, AC-treated diabetic, and glibenclamide-treated diabetic groups. For induction of type 1 diabetes, streptozotocin at a dose of 60 mg/kg (i.p) was injected. Treated groups received AC-mixed pelleted food at a weight ratio of 6.25%. Body weight and serum glucose level was measured before the study and after 4 and 8 weeks. At the end of study, contractile reactivity of thoracic aortic rings to KCl and phenylephrine and relaxatory response to acetylcholine and sodium nitroprusside was determined using isolated tissue setup. Results: Serum glucose level significantly decreased in AS-treated diabetic group (P | en |
| DOI | https://doi.org/ | en |
| Keyword | Maranthus caudatus, Diabetes mellitus, Endothelium, Aorta, Thoracic, Rats | en |
| Keyword | تاج خروس، دیابت شیرین، اندوتلیوم، آئورت سینه ای، موش صحرایی | en |
| Publisher | Brieflands | en |
| Title | Endothelium-dependent effect of Amaranthus caudatus feeding on contractile properties of thoracic aorta from diabetic rats | en |
| Type | Research Article | en |
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