Investigating <i>HOTAIR</i> Polymorphisms as a Potential Diagnostic Marker for Type 2 Diabetes in an Iraqi Population
| Author | Zainab Hadi Talib | en |
| Author | Amir Jalali | en |
| Author | Abbass Haydar | en |
| Orcid | Amir Jalali [0000-0002-3592-5789] | en |
| Issued Date | 2024-12-31 | en |
| Abstract | Background: Diabetes mellitus type 2 (T2DM) is a chronic condition characterized by insulin resistance, affecting approximately 530 million adults globally, with a prevalence of 10.5% among individuals aged 20 to 79. In Iraq, the prevalence is significantly higher at 13.9%. Objectives: This study examines the relationship between long noncoding RNA HOX transcript antisense RNA (HOTAIR) polymorphisms and T2DM risk, investigating HOTAIR's potential as a diagnostic marker. Methods: Blood samples were collected from 28 T2DM patients and 20 healthy controls, with physiological parameters measured. HOTAIR plasma levels were assessed using quantitative real-time (qRT)-PCR, and single-nucleotide polymorphisms rs12826786 and rs1899663 were analyzed through amplification refractory mutation system (ARMS)-PCR. Results: HOX transcript antisense RNA expression was found to be 6.6 times higher in T2DM patients compared to controls, suggesting its involvement in T2DM pathophysiology. Genotype distributions adhered to Hardy-Weinberg equilibrium, with the rs12826786 C allele appearing protective against T2DM, while rs1899663 showed no significant association. Statistical analysis identified a significant relationship between the rs12826786 genotype and body mass index (BMI), though other diabetes-related metrics did not show significant results. Conclusions: The findings suggest that elevated HOTAIR expression may play a role in T2DM, highlighting the need for further investigation into these associations and their potential implications for diagnosis and risk assessment. | en |
| DOI | https://doi.org/10.5812/jjcmb-154415 | en |
| Keyword | Diabetes Mellitus | en |
| Keyword | <i>HOTAIR</i> | en |
| Keyword | Long Non-coding RNA | en |
| Keyword | Single-Nucleotide Polymorphisms | en |
| Keyword | Glucose Metabolism Disorder | en |
| Keyword | Iraq | en |
| Publisher | Brieflands | en |
| Title | Investigating <i>HOTAIR</i> Polymorphisms as a Potential Diagnostic Marker for Type 2 Diabetes in an Iraqi Population | en |
| Type | Research Article | en |
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