Efficacy of Dexmedetomidine Infusion Without Loading Dose on Hemodynamic Variables and Recovery Time During Craniotomy: A Randomized Double-blinded Controlled Study
| Author | Ismail Mohammed Ibrahim | en |
| Author | Rania Hassan | en |
| Author | Raham Hasan Mostafa | en |
| Author | Mayada Ahmed Ibrahim | en |
| Orcid | Ismail Mohammed Ibrahim [0000-0002-5182-4195] | en |
| Orcid | Rania Hassan [0000-0001-9523-9281] | en |
| Orcid | Raham Hasan Mostafa [0000-0002-5560-2733] | en |
| Orcid | Mayada Ahmed Ibrahim [0000-0001-9451-5379] | en |
| Issued Date | 2021-04-30 | en |
| Abstract | Background: Maintaining hemodynamic stability during intracranial surgery is one of the most important tasks. There is no general agreement regarding which anesthetics are optimal for craniotomy. Propofol and short-acting opioids are usually used, but their use is not without side effects. Recently, dexmedetomidine has been considered a safe alternative in different surgeries. Objectives: We aimed to assess the efficacy of 0.5 µg/kg/h dexmedetomidine infusion without loading dose as an adjunct to general anesthesia for craniotomy. Methods: A prospective, randomized, double-blinded, parallel-group, placebo-controlled trial was conducted. Setting: Single university teaching hospital’s operating rooms and postoperative intensive care unit. Patients: A total of 50 patients scheduled for elective supratentorial craniotomy participated in this study. Interventions: Patients were randomly divided into either control group (group C) and Dexmedetomidine group (group D). Main outcome measure: Intraoperative hemodynamics measurements at specific timings. Results: We found that dexmedetomidine had significantly maintained mean arterial blood pressure and heart rate (P-value < 0.001); with lower intraoperative fentanyl and propofol consumption in group D (132 ± 35 µg and 14 ± 30 mg, respectively) when compared to group C (260 ± 38 µg and 534 ± 66 mg, respectively). Finally, a lesser sedation level was noticed in the dexmedetomidine group, together with a significantly lesser recovery time of 10.3 ± 4 min. Conclusions: Dexmedetomidine infusion without loading dose could be an efficacious and safe agent in achieving hemodynamic stability with intraoperative opioid-sparing effect and lesser recovery time. | en |
| DOI | https://doi.org/10.5812/aapm.113410 | en |
| Keyword | Craniotomy | en |
| Keyword | Dexmedetomidine | en |
| Keyword | Hemodynamics | en |
| Keyword | Recovery | en |
| Publisher | Brieflands | en |
| Title | Efficacy of Dexmedetomidine Infusion Without Loading Dose on Hemodynamic Variables and Recovery Time During Craniotomy: A Randomized Double-blinded Controlled Study | en |
| Type | Research Article | en |
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