Comparing the Apelin Level in Hypertensive Patients Who Received Hypertension Drugs
| Author | Mina Hemmati | en |
| Author | Fatemeh Abharzanjani | en |
| Author | Tooba Kazemi | en |
| Author | Fateme Estanesti | en |
| Orcid | Mina Hemmati [0000-0001-9401-5067] | en |
| Orcid | Fatemeh Abharzanjani [0000-0002-0819-4933] | en |
| Orcid | Tooba Kazemi [0000-0002-6204-4514] | en |
| Issued Date | 2020-10-31 | en |
| Abstract | Background: Apelin, an adipokine secreted from adipose tissue, plays an important role in regulating blood pressure and hypertension. Objectives: The current study aimed to compare the plasma Apelin level in hypertensive patients under treatment with amlodipine, losartan, and amlodipine + losartan. Methods: In this case-control study, the serum level of Apelin was compared in four groups of (A) Healthy subjects (n = 31); (B) Hypertensive patients, received amlodipine (n = 31); Hypertensive patients, received losartan (n = 45); and patients (n = 33) that received amlodipine and losartan. Apelin level in serum samples was measured using Human Apelin ELISA Kit according to the manufacturers’ instructions. Data were analyzed using SPSS version 19 (Chicago: SPSS Inc.), at the significant level of α = 0.05. Results: The mean blood level of Apelin in the control group and groups receiving amlodipine, losartan, and amlodipine + losartan was 366.16 ± 36.04, 247.19 ± 27.77, 282.93 ± 47.08, and 289.84 ± 32.20 g/dl, respectively. Losartan + amlodipine group had a higher level of Apelin compared with amlodipine alone (P < 0.05). Conclusions: This study demonstrated that Apelin has a definite protective effect in preventing hypertension. Also, according to the results, the renin-angiotensin-aldosterone system inhibitors, such as losartan, caused a higher increase in the Apelin, resulting in better blood pressure control. | en |
| DOI | https://doi.org/10.5812/modernc.106150 | en |
| Keyword | Apelin | en |
| Keyword | Hypertension | en |
| Keyword | Amlodipine | en |
| Keyword | Losartan | en |
| Keyword | Calcium Channel Blocker Receptor | en |
| Keyword | Angiotensin II Receptor Antagonists | en |
| Publisher | Brieflands | en |
| Title | Comparing the Apelin Level in Hypertensive Patients Who Received Hypertension Drugs | en |
| Type | Research Article | en |
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