Research on Obesity: A Quarter-Century Experience from the Tehran Lipid and Glucose Study

AuthorSara Sadeghien
AuthorBehnaz Abirien
AuthorFarhad Hosseinpanahen
AuthorMajid Valizadehen
AuthorFereidoun Azizien
AuthorMaryam Mahdavien
AuthorMaryam Barzinen
OrcidFereidoun Azizi [0000-0002-6470-2517]en
OrcidMaryam Barzin [0000-0001-7718-1952]en
Issued Date2026-04-30en
AbstractContext: This paper aims to synthesize a quarter-century of research on obesity from the Tehran Lipid and Glucose Study (TLGS), a large prospective population-based cohort. Evidence Acquisition: A comprehensive literature search identified original studies from the TLGS investigating obesity indices, body composition, obesity phenotypes, and their associations with cardiometabolic outcomes. Results: Tehran Lipid and Glucose Study findings demonstrate alarming increases in the prevalence and incidence of general and abdominal obesity among Tehranian adults and children. The studies have established population-specific anthropometric cut-offs, revealed the complex associations of various obesity phenotypes with type 2 diabetes, cardiovascular disease, and chronic kidney disease, and highlighted the critical role of metabolic health over weight status alone. Conclusions: This substantial body of evidence provides crucial insights for crafting effective public health strategies and future research in transitioning populations.en
DOIhttps://doi.org/10.5812/ijem-168110en
URIhttps://brieflands.com/journals/ijem/articles/168110en
KeywordTehran Lipid and Glucose Studyen
KeywordTLGSen
KeywordObesityen
KeywordCohort Studiesen
KeywordCardiometabolic Risk Factorsen
KeywordIranen
PublisherBrieflandsen
TitleResearch on Obesity: A Quarter-Century Experience from the Tehran Lipid and Glucose Studyen
TypeReview Articleen

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