Association of Two MMP-8 Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women
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Abstract
Background: It has been reported that less than 5% of women experience recurrent pregnancy loss (RPL). different matrix metalloproteinases (MMPs) have proteolysis function with a main role in the stable development of the fetus.
Objective: This study aims to assess the associations between two single nucleotide polymorphisms (rs2509013 C>T and rs11225395 G>A) of MMP-8 gene and RPL among 130 Iranian women with a history of RPL and 130 controls.
Methods: Genotyping of the MMP-8 gene was done for the two polymorphisms by using Sanger sequencing method.
Results: High frequency of AA genotype (OR: 2.5, 95%CI:1.02-4.1, P