Association of Two MMP-8 Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women
| Author | Reza Najafipour | en |
| Author | Zahar Rashvand | en |
| Author | Khadijeh Taherkhani | en |
| Author | Solmaz Chamanara | en |
| Author | Shokoh Abotorabi | en |
| Author | Sahar Moghbelinejad | en |
| Issued Date | 2021-12-31 | en |
| Abstract | Background: It has been reported that less than 5% of women experience recurrent pregnancy loss (RPL). different matrix metalloproteinases (MMPs) have proteolysis function with a main role in the stable development of the fetus. Objective: This study aims to assess the associations between two single nucleotide polymorphisms (rs2509013 C>T and rs11225395 G>A) of MMP-8 gene and RPL among 130 Iranian women with a history of RPL and 130 controls. Methods: Genotyping of the MMP-8 gene was done for the two polymorphisms by using Sanger sequencing method. Results: High frequency of AA genotype (OR: 2.5, 95%CI:1.02-4.1, P | en |
| DOI | https://doi.org/ | en |
| Keyword | Recurrent pregnancy loss | en |
| Keyword | Matrix metalloproteinase | en |
| Keyword | MMP-8 | en |
| Keyword | Polymorphism | en |
| Publisher | Brieflands | en |
| Title | Association of Two MMP-8 Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women | en |
| Type | Research Article | en |
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