Fibrinogen and Fibrin Degradation Products’ Levels in Cardiopulmonary Bypass with Mild-Hypothermia versus Normothermia
| Author | Bahram Ghasemzade | en |
| Author | Motahare Ghodrati | en |
| Author | Naser Kachoeian | en |
| Author | Yadollah Banakar | en |
| Author | Farhad Gorjipour | en |
| Author | Ali Asghar Zarei | en |
| Author | Hosein Zaree | en |
| Orcid | Motahare Ghodrati [0000-0003-3813-1180] | en |
| Issued Date | 2020-09-30 | en |
| Abstract | Background: Coagulation cascades are activated during Cardiopulmonary Bypass (CPB) and their proper monitoring and maintenance determine the outcomes of operation to a big extent. Here, we assessed serum fibrinogen and Fibrin Degradation Products (FDP) in adult patients undergoing CABG with using CPB, either with hypothermia or normothermia. Materials and Methods: In a cross-sectional study, 80 adult patients’ candidate for elective CABG were randomly assigned into two groups: hypothermia and normothermia to assess fibrinogen and FDP, perioperatively. Results: Patients included 32 men (80%) in the hypothermia group and 26 men (60%) in the normothermia with the mean age of 61.43 ± 12.64 years. The mean temperature in the hypothermia group was 32.33 ± 1.44 and 35.33 ± 0.71 in the normothermic group. Differences in fibrinogen levels between the two groups were not significant (Fib before CPB, P=0.893, and Fib after declamping, P=0.057). The serum level of FDP before and during CPB was not significantly different in hypothermia and normothermia groups (P=0.412, P=0.778, respectively). Conclusion: During cardiac surgery in hypothermia and normothermia conditions rate of fibrinogen decreased 25% after declamping in each group; this decrease seems to be due to hemodilution. FDP levels were similar in both groups. | en |
| DOI | https://doi.org/10.22037/jcma.v5i3.30324 | en |
| Keyword | Fibrinogen | en |
| Keyword | fibrin degradation products (FDPs) | en |
| Keyword | Hypothermia | en |
| Keyword | cardiopulmonary bypass | en |
| Publisher | Brieflands | en |
| Title | Fibrinogen and Fibrin Degradation Products’ Levels in Cardiopulmonary Bypass with Mild-Hypothermia versus Normothermia | en |
| Type | Research Article | en |
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