Seroprevalence of Cytomegalovirus Antibody in Renal Transplant Recipients and Donors in Khuzestan Province, Iran

Abstract

Objective: Cytomegalovirus (CMV) has been recognized as one of the most important opportunistic pathogens in kidney transplant patients. The aim of this study was to determine the prevalence of CMV antibody in donors and recipients before transplantation. Materials and Methods: In a cross sectional study from March 2008 to August 2009 we prospectively studied donors and recipients who referred to our kidney transplant center. All of routine pretransplante laboratory studies including liver function tests and CMV IgG and IgM antibody were performed for them. Results: A total of 148 patients (79 donors and 69 recipients) were included in the study. Mean age of donors and recipients were 30 8 years and 40 18 years respectively. Liver Function tests (SGOT and SGPT) were at normal range and marker of HBV infection was negative in both groups but HCV antibody was positive in 2.89 percent of recipients (n=2) and negative in all of donors. CMV IgG antibody was positive in 100 percent of recipients and 98.73 percent of donors (n=78). CMV IgM antibody was negative in 98.55 percent of recipients (n=68) and 100 percent of donors (n=79). Conclusion: CVM infection is very common in donors and recipients candidate for kidney transplantation in Khuzestan province and almost all of them in this study have CMV IgG antibody