Effect of Nandrolone Treatment with and without Resistance Training on Superoxide Dismutase Concentration and Pathology of Kidney Tissue in Rats
| Author | Esfandiyar Heidari | en |
| Author | Seyed Ali Hosseini | en |
| Author | Mohammad Ali Azarbayjani | en |
| Orcid | Seyed Ali Hosseini [0000-0001-9122-3952] | en |
| Orcid | Mohammad Ali Azarbayjani [0000-0002-3502-7487] | en |
| Issued Date | 2020-12-31 | en |
| Abstract | Background: The prevalence of anabolic steroids abuse in athletes and non-athletes is associated with the risk of injury to various organs, but there are limited studies of oxidative changes in kidney tissue following nandrolone (N) administration. Objectives: the aim of this study was to investigate the effect of N treatment with and without resistance training (RT) on superoxide dismutase (SOD) concentration and tissue pathology of kidney tissue in rats. Methods: In this experimental study, 20 male Wistar rats were randomly divided into four groups of five rats including 1) control (C), 2) sham (normal saline) (Sh), 3) N, and 4) N + RT. Groups 3 and 4 received 10 mg/kg N peritoneally, and the N + RT group performed 1 m ladder climbing for eight weeks and three sessions per week. SOD levels of kidney tissue were measured by ELISA and radioimmunoassay. Hematoxylin-eosin (H&E) staining was used to evaluate oxidative stress levels in kidney tissue. One-way ANOVA with Bonferroni’s post- hoc tests were used for analysis of research findings in SPSS version 22 (P ≤ 0.05). Results: SOD levels in the C group were higher than the Sh (P = 0.001), N (P = 0.001), and N + RT (P = 0.001) groups. SOD levels were lower in the Sh group than in the N (P = 0.049) and N + RT (P = 0.001) groups. However, there was no significant difference in SOD levels in the N + RT group and N group (P = 0.28). Also, oxidative stress levels were normal in tissue studies in all groups. Conclusions: It seems that N treatment with and without RT reduces SOD activity in kidney tissue, but more studies are needed in this regard given the normality of tissue oxidative stress results. | en |
| DOI | https://doi.org/10.5812/jcrps.102497 | en |
| Keyword | Nandrolone | en |
| Keyword | Resistance Training | en |
| Keyword | Superoxide Dismutase | en |
| Keyword | Kidney | en |
| Publisher | Brieflands | en |
| Title | Effect of Nandrolone Treatment with and without Resistance Training on Superoxide Dismutase Concentration and Pathology of Kidney Tissue in Rats | en |
| Type | Research Article | en |