Lack of Association Between Superoxide Dismutase Gene Polymorphism and Malignant Lymphoproliferative Disorders

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AuthorAlireza Nakhaeeen
AuthorMohammad Ali Mashhadien
AuthorMohaddeseh Zademiren
AuthorZahra Sepehrien
AuthorDerek Kennedyen
Issued Date2016-07-01en
AbstractBackground: Superoxide dismutase is one of the most important antioxidant enzymes that protect cells against destructive effects of superoxide anion. Objectives: The aim of this study was to evaluate the association between the C47T polymorphism (rs4880) of the manganese superoxide dismutase (Mn-SOD) gene and the risk of malignant lymphoproliferative disorders (MLDs). Patients and Methods: Manganese superoxide dismutase polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 103 patients with MLDs and 103 healthy control subjects. Results: The frequencies of the CC, CT and TT genotypes were 29.1%, 51.5% and 19.4%, respectively, in patients with MLDs and 24.3%, 47.6% and 28.2%, respectively, in the control group. There were no statistical differences in the genotype or allele frequency of rs4880 between cases and controls. Conclusions: According to the fact that Mn-SOD gene polymorphisms have been considered as a major risk factor in some malignancies, this single center study did not find any association between the rs4880 polymorphism of the manganese superoxide dismutase gene and risk of MLDs.en
DOIhttps://doi.org/10.17795/gct-37768en
KeywordSuperoxide Dismutaseen
KeywordPolymorphismen
KeywordLymphoproliferative Disordersen
KeywordPCR-RFLPen
PublisherBrieflandsen
TitleLack of Association Between Superoxide Dismutase Gene Polymorphism and Malignant Lymphoproliferative Disordersen
TypeResearch Articleen

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