The Influence of Supplemental Vitamin C on Glycosylated Hemoglobin in Patients with Type 2 Diabetes Mellitus

Abstract

There is evidence implying the influence of vitamin C on prevention of hemoglobin glycation. The aim of the present study was to investigate the effect of vitamin C on the level of glycosylated hemoglobin (HbAlc) in patients with type 2-diabetes. Materials and Methods: 18 patients with type 2 diabetes (14 females, 4 males) were enrolled in a clinical trial study. 1000 mg of supplemental vitamin C (divided into 4 doses) per day was given to the subjects for 6 weeks. Body mass index (BMI), a 3-day diet recall, fasting plasma glucose and glycosylated hemoglobin were measured before and after the administration of supplemental vitamin C. Data were analyzed by paired t-test. Results: Body weight and BMI were slightly higher at the end of study, as compared to before. Glycosylated hemoglobin level decreased significantly at the end of study 1l.8±1.48 vs, 10.2±1.28%, (p