Suppression of Menstrual-Related Migraine Attack Severity Using Pyridoxine, Thiamine, and Cyanocobalamin: A Quasi-Experimental Within-Subject Design
| Author | Mansoureh Togha | en |
| Author | Reza Rahmanzadeh | en |
| Author | Shiva Nematgorgani | en |
| Author | Zahra Yari | en |
| Author | Soodeh Razeghi Jahromi | en |
| Author | Farshid Refaeian | en |
| Issued Date | 2020-06-02 | en |
| Abstract | Background: B-group vitamins can potentially contribute to migraine prophylaxis through various mechanisms. We conducted a quasi-experimental study to assess the efficacy and tolerability of a combination of vitamins B1, B6, and B12 (Neurobion) for prophylaxis of menstruation-related migraine attacks. Methods: Women diagnosed with menstrual-related migraine, both chronic and episodic headaches, were enrolled. The patients began Neurobion therapy one week before the menstruation cycle, and repeated the injection for three consecutive months; each ampoule contained 100 mg of vitamins B1 and B6 as well as 1000 μg of vitamin B12. Neurobion was used as an add-on therapy for patients receiving the same prophylactic therapy during the last two months before the start of the study. The outcome parameter examined the severity of menstrual-related migraine attacks on a 10-point visual analog scale (VAS). Results: Three hundred eighty-three patients (169 with chronic migraine and 214 with episodic migraine) were included in the final analysis. The patients received treatment with a combination of vitamins B1, B6, and B12 with positive results. The mean intensity of menstrual-related migraine attacks was reduced from 6.7 on the 10-point VAS to 3.2 (P < 0.001) in patients with chronic migraine. The mean severity of menstrual-related migraine attacks was also reduced from 7.2 to 3.7 in patients with episodic migraine (P < 0.001). There was no significant difference in the reduction of headache severity between the two groups of migraineurs (P = 0.985). Conclusions: Neurotropic vitamins, including pyridoxine, thiamine, and cyanocobalamin yielded significant reductions in the severity of menstrual-related migraine attacks. Neurobion as a combination of vitamins B1, B6, and B12 appears to be well-tolerated and beneficial as an adjuvant in treatment and prophylaxis of menstrual-related migraine attacks. Further large-scale trials with long-term follow-up will be required to confirm our results. | en |
| DOI | https://doi.org/10.5812/ans.93103 | en |
| Keyword | Migraine | en |
| Keyword | Headache | en |
| Keyword | Prophylaxis | en |
| Keyword | Neurobion | en |
| Keyword | Neurotropic | en |
| Keyword | Group B Vitamins | en |
| Keyword | Vitamin B1 | en |
| Keyword | Vitamin B6 | en |
| Keyword | Vitamin B12 | en |
| Publisher | Brieflands | en |
| Title | Suppression of Menstrual-Related Migraine Attack Severity Using Pyridoxine, Thiamine, and Cyanocobalamin: A Quasi-Experimental Within-Subject Design | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ans-7-3-93103.pdf
- Size:
- 137.23 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF