Protective Effect of Aspirin in Relation to IGF-1 in Streptozotocin Induced Type-II Diabetic Rats

Abstract

background:The present study aimed at investigating the protective effects of aspirin in relation to insulin like growth factor-1 (IGF-1) in streptozotocin (STZ) induced type-2 diabetic rats.Materials and Methods: Rat pups were divided into four groups; on the 5th day of their age, group-I pups received citrate buffer solution and served as the normal group; group-II, treated on-ly with streptozotocin (80 mg/kg, i.p), served as the diabetic group; groups-III & IV, treated with aspirin (10 mg/kg/day, p.o) for one month (5-35 days) and two months (5-65 days) after streptozo-tocin, served as the treated groups. On the 35th and 65th days, blood samples were collected from all animals and fasting blood sugar, fasting insu-lin, IGF-1, insulin resistance and insulin sensi-tivity levels were estimated. Results: Blood samples taken on the 35th & 65th days, from pups treated with streptozotocin per se and in combination with aspirin for one and two months showed significantly increased body weight, fasting blood glucose and insulin resis-tance levels and significantly lowered fasting in-sulin and insulin sensitivity levels, when com-pared to the normal control pups respectively. Pups treated with aspirin for one month had significantly raised IGF-1 levels, whereas those with two month treatments had significantly lo-wered IGF-1 levels when compared to the nor-mal pups (p