Deficits in Striatal Dopamine and Hippocampal Serotonin Following Induction of Anxiety/Depressive-Like Behaviors by Bisphenol A
| Author | Meng Jia | en |
| Author | Julian Pittman | en |
| Issued Date | 2015-01-01 | en |
| Abstract | Background: Anxiety and depression are common nonmotor symptoms of Parkinson’s disease (PD). Objectives: We investigated whether Bisphenol A (BPA) is capable of inducing anxiety/depressive-like behaviors and neurotransmitter alterations that are similar to those observed in PD. Materials and Methods: To test this hypothesis, we used a zebrafish animal model and conducted behavioral and histological assays. Results: BPA produced anxiety/depression-like behavioral signs for 14 days following administration. Altered behavioral responses were accompanied by reductions of striatal dopamine transporter, and decrease in hippocampal 5-HT content. Conclusions: These results suggest that the nigrostriatal pathway might play a role in the etiology of anxiety/depression. Furthermore, dopamine transporter function, in particular, might play a critical role in the pathophysiology of anxiety/depression. | en |
| DOI | https://doi.org/10.5812/archneurosci.18555 | en |
| Keyword | Anxiety | en |
| Keyword | Depression | en |
| Keyword | Dopamine | en |
| Keyword | Serotonin | en |
| Keyword | Parkinson’s Disease | en |
| Publisher | Brieflands | en |
| Title | Deficits in Striatal Dopamine and Hippocampal Serotonin Following Induction of Anxiety/Depressive-Like Behaviors by Bisphenol A | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 55877-pdf.pdf
- Size:
- 613.65 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF