Effects of Clonidine Premedication on Intraoperative Blood Loss in Patients With and Without Opium Addiction During Elective Femoral Fracture Surgeries
| Author | Davood Ommi | en |
| Author | Houman Teymourian | en |
| Author | Alireza Zali | en |
| Author | Farzad Ashrafi | en |
| Author | Morteza Jabbary Moghaddam | en |
| Author | Alireza Mirkheshti | en |
| Orcid | Alireza Mirkheshti [0000-0003-2781-5843] | en |
| Issued Date | 2015-08-01 | en |
| Abstract | Background: Opium is an addictive agent and one of the most common narcotics With great challenges of intraoperative hemodynamic instabilities. Objectives: The current study aimed to assess the effects of clonidine on intraoperative blood loss in patients with and without opium addiction in femoral fracture surgeries. Patients and Methods: In a randomized clinical trial, 160 candidates for elective femoral fracture operations under general anesthesia were divided into four groups of 40 subjects: group 1 (placebo 1), subjects without addiction received placebo 90 minutes before the operation; group 2 (placebo 2), patients with opium addiction received placebo as group 1; group 3 (Clonidine 1), patients without addiction received clonidine 90 minutes before the operation and group 4 (Clonidine 2), patients with opium addiction received clonidine as premedication. Results: Intraoperative blood loss in clonidine recipient groups, patients with and without addiction, was less than that of the placebos (both P values < 0.01) and the difference magnitude was higher in patients with opium addiction. Conclusions: Premedication with clonidine to decrease intraoperative blood loss can be more effective in patients with opium addiction than the ones without addiction. | en |
| DOI | https://doi.org/10.5812/aapm.23626 | en |
| Keyword | Opium | en |
| Keyword | Clonidine | en |
| Keyword | Substance Abuse | en |
| Keyword | Hemorrhage | en |
| Publisher | Brieflands | en |
| Title | Effects of Clonidine Premedication on Intraoperative Blood Loss in Patients With and Without Opium Addiction During Elective Femoral Fracture Surgeries | en |
| Type | Research Article | en |
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