The effect of long-term oral administration of Nigella. sativum on the contractile reactivity of thoracic aorta in diabetic rats
| Author | Mehrdad Roghani | en |
| Author | ToranDokht BalochnejadMojarad | en |
| Author | MohammadReza VaezMahdavi | en |
| Author | Mohammad Vaseie | en |
| Orcid | Mehrdad Roghani [0000-0002-9209-8484] | en |
| Issued Date | 2006-09-30 | en |
| Abstract | Introduction: Therapeutics, especially medical plants with minimum side-effects are of high value in preventing vascular complications of diabetes mellitus in long term. Considering the evidences about the anti-diabetic effects of Nigella. Sativum (NS), the current study was conducted to evaluate the effect of oral two-month administration of NS on the contractile reactivity of isolated aorta in male diabetic rats. Material & Methods: Male Wistar rats (n=32) were randomly divided into control, NS-treated control, diabetic, and NS-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was intraperitoneally administered. The treatment groups were received oral administration of NS-mixed pelleted food (6.25%) for two months. After two months, the contractile reactivity of aortic rings to KCl and noreadrenaline was determined using isolated tissue setup. Results: Contractile response to cumulative KCl and noreadrenaline followed a dose-dependent pattern in aortic rings in all groups. In addition, the maximum contractile reactivity was significantly higher in the diabetic group compared to the control one (p | en |
| DOI | https://doi.org/ | en |
| Keyword | Nigella sativum, Vascular System, Diabetes Mellitus, Contractile Response, Rat | en |
| Keyword | سیاهدانه، سیستم عروقی، دیابت قندی، پاسخ انقباضی، موش صحرایی | en |
| Publisher | Brieflands | en |
| Title | The effect of long-term oral administration of Nigella. sativum on the contractile reactivity of thoracic aorta in diabetic rats | en |
| Type | Research Article | en |
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