A Survey of Fecal Calprotectin in Children with Newly Diagnosed Celiac Disease with Villous Atrophy
| Author | Iraj Shahramian | en |
| Author | Ali Bazi | en |
| Author | Negar Shafie-Sabet | en |
| Author | Alireza Sargazi | en |
| Author | Omolbanin Sargazi Aval | en |
| Author | Mojtaba Delaramnasab | en |
| Author | Mohadeseh Behzadi | en |
| Author | Zahra Zaer-Sabet | en |
| Orcid | Iraj Shahramian [0000-0002-4134-1405] | en |
| Orcid | Ali Bazi [0000-0003-4872-1352] | en |
| Orcid | Alireza Sargazi [0000-0003-1937-6051] | en |
| Orcid | Mojtaba Delaramnasab [0000-0002-2958-3671] | en |
| Issued Date | 2019-07-02 | en |
| Abstract | Background: Fecal calprotectin (FC) has been used as a diagnostic marker in intestinal inflammatory conditions. Objectives: As a few studies have been dedicated to assess the role of FC in coeliac disease (CD), the current study aimed to address this issue. Methods: This study included 70 newly diagnosed CD (Marsh score 3) and 70 healthy children. The study was performed at the pediatric ward of Amir-Al-Momenin Hospital in Zabol city, the southeast of Iran, during June 2016-September 2017. The FC level was determined using a specific ELISA kit. Results: Women constituted 64.3% (45/70) and 55.1% (38/70) of CD and healthy children, respectively (P = 0.1). Three was no significant difference in the mean age between children with CD (6.3 ± 3.4) and without CD (8.3 ± 4.5) (P = 0.2). The mean level of FC was significantly higher in patients (239.1 ± 177.3 μg/g) than in healthy controls (38.5 ± 34.6 μg/g, P < 0.001). The titer of anti-tTG was significantly higher in patients than in healthy children (205.9 ± 156.2 U/mL vs. 6.7 ± 2.1 U/mL, respectively, P < 0.001). There was a significant correlation between the FC level and anti-tTG titer (r = 0.611, P < 0.001). However, the correlation was not statistically significant between FC and age (r = -0.154, 0.07). The ROC curve analysis revealed an AUC value of 0.893 (95% CI: 0.827 - 0.960, P < 0.001). At the level of 50 μg/g, FC rendered the sensitivity and specificity of 90% and 92%, respectively, for the diagnosis of CD. Positive predictive value (PPV) and negative predictive value (NPV) of FC at this cutoff value were 95.5% and 90.5%, respectively. Conclusions: FC can be considered a screening complementary tool for detecting CD with high sensitivity and specificity. | en |
| DOI | https://doi.org/10.5812/semj.84514 | en |
| Keyword | Fecal Calprotectin | en |
| Keyword | Celiac Disease | en |
| Keyword | Gluten Enteropathy | en |
| Keyword | Marsh Score | en |
| Publisher | Brieflands | en |
| Title | A Survey of Fecal Calprotectin in Children with Newly Diagnosed Celiac Disease with Villous Atrophy | en |
| Type | Research Article | en |
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