Kidney Graft Recipients Bone Mineral Density in Iranian

Abstract

Renal transplantation triggers an early bone loss that increases the subsequent risk of osteoporosis and fractures. Little is known about the outcome of bone status after transplantation, specially, in-patient of southwest region of Asia. Therefore, we conducted a cross-sectional evaluation of bone status to find out the frequency and predictors of osteoporosis in kidney graft recipients patients in Iran. Spinal and hipbone mineral density were assessed using a DEXA Lunar DPX-MD scanner in 61 renal graft recipients in Tehran, Iran. In this study, 44% of patients were men (27) and 56% of them were women (34). Mean of age of them was accordingly 44.3± 10.44 and 40/7± 13.77. Mean of transplant duration was 33.9± 33. 2 months (minimum was 3 month and maximum 172 months). Mean of dialysis time was 12± 14 months ( 0-72 months ). Osteoporosis, according to the World Health Organization definition, was observed in 18 patients (29.5% of the total population) in any of the Total or Neck or L2-L4 region (14.8% in Neck, 19.7% in Total, 16.4% in L2-L4 regions). Frequency of osteoporosis was significantly higher in lowest BMI group (p = 0.007). Age, sex, transplantation duration, dialysis time, cause of renal failure, steroid cumulative dosage, cyclosporine cumulative dosage, had no significant relationship with bone loss in any of regions. These data emphasize the high prevalence of osteoporosis in Iranian kidney graft recipients. Screening and therapeutic intervention in these patients is urgently needed.