Protective Effects of the Combination of Exercise and Gallic Acid Supplementation on Cardiac System in CaCl2-Induced Arrhythmias Model in rats
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Date
2018-10-31
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Brieflands
Abstract
Introduction: Cardiovascular disease is currently the most common global disease. Cardiac arrhythmia is one of the most common types of heart diseases and main cause of mortality. Gallic acid (GA), as an antioxidant agent, has many preventive effects on diseases, and its Cardioprotective activity in myocardial infarction has been also reported. On the other hand, it is well documented that exercise-induced increase in myocardial manganese antioxidant activity is vital for protection against cardiac injuries. Thus, the present study investigated the antiarrhythmic activity of exercise training and GA supplementation alone or combined, on CaCl2-induced arrhythmia in rats.Materials and Methods: In this study, 32 male Sprague-Dawley rats (4-6 months old and weighing 200-250 g) were randomly assigned to four groups: Control, GA (50 mg/kg, gavage, 10 days), Exercise (21-days) and Exercise+GA. Then, lead II electrocardiogram was recorded to calculate HR and voltage of QRS complex. Also, the percentage of ventricular premature beats (VPB), ventricular fibrillation (VF) and ventricular tachycardia (VT) were recorded after the injection of CaCl2 (140 mg/kg, i.v) in all groups. Results were analyzed by using ANOVA and Fisher’s exact test and P