A comparative study of influence of isoflurane and propofol on IL1, IL6, TNF serum levels after craniotomy for supratentorial brain tumors
| Author | Farhad Safari | en |
| Author | Parisa Sezari | en |
| Author | Kamran Mottaghi | en |
| Author | Bahareh Torbat Isfahani | en |
| Author | Masoud Nashibi | en |
| Orcid | Farhad Safari [0000-0002-1479-8477] | en |
| Orcid | Parisa Sezari [0000-0003-3874-1050] | en |
| Orcid | Kamran Mottaghi [0000-0003-3371-1047] | en |
| Orcid | Bahareh Torbat Isfahani [0009-0004-9663-9913] | en |
| Orcid | Masoud Nashibi [0000-0003-3825-9889] | en |
| Issued Date | 2019-03-31 | en |
| Abstract | Background: The purpose of this randomized, single-center study was to prospectively investigate the impact of anesthetic techniques for craniotomy on the release of cytokines (interleukin (IL)-1, IL-6, tumor necrosis factor factor-alpha (TNF-?)) and to determine whether intravenous anesthesia compared to inhalational anesthesia attenuates the inflammatory response.Methods and Materials: The study enrolled 60 patients undergoing craniotomy, allocated into two equal groups to receive either Isoflurane (n=30) and Propofol (n=30). Non-invasive hemodynamic monitoring was used. Serum levels of IL-1, IL-6 and TNF-? were evaluated before and at the end of surgery and anesthesia.Results: Although there was a significant rise in serum level of inflammatory cytokine but compared with patients anaesthetized with Isoflurane, patients who received Propofol had significant lower levels of IL-1, IL-6 and TNF-a after surgery (p | en |
| DOI | https://doi.org/10.22037/jcma.v4i1.25315 | en |
| Keyword | Craniotomy | en |
| Keyword | Propofol | en |
| Keyword | Isoflurane | en |
| Keyword | Interleukin 1 | en |
| Keyword | Interleukin 6 | en |
| Keyword | TNF-a | en |
| Publisher | Brieflands | en |
| Title | A comparative study of influence of isoflurane and propofol on IL1, IL6, TNF serum levels after craniotomy for supratentorial brain tumors | en |
| Type | Original Articles | en |
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