Relationships Between Various Components of Metabolic Syndrome and Chronic Kidney Disease in Shiraz, Iran
| Author | Marzieh Bakhshayeshkaram | en |
| Author | Jamshid Roozbeh | en |
| Author | Seyed Taghi Heidari | en |
| Author | Behnam Honarvar | en |
| Author | Mohammad Hossein Dabbaghmanesh | en |
| Author | Kamran B. Lankarani | en |
| Orcid | Jamshid Roozbeh [0000-0002-4268-1727] | en |
| Orcid | Seyed Taghi Heidari [0000-0001-7711-1137] | en |
| Orcid | Behnam Honarvar [0000-0002-1081-5778] | en |
| Orcid | Mohammad Hossein Dabbaghmanesh [0000-0002-4877-0376] | en |
| Orcid | Kamran B. Lankarani [0000-0002-7524-9017] | en |
| Issued Date | 2019-04-30 | en |
| Abstract | Background: Chronic kidney disease (CKD) can potentially be associated with metabolic syndrome (MetS). Objectives: We aimed to determine the association of MetS and the number of metabolic syndrome components with the risk of CKD in the Iranian population in southern Iran. Methods: A total of 819 subjects aged 18 - 88 years were enrolled using weight-based random cluster sampling. We constructed a logistic regression model to determine the adjusted odds ratios (ORs) and 95% confidence intervals (CI) of the association of MetS individual components and the number of these components with CKD. Results: The prevalence rate of MetS was 25.9% (30.9% in women and 18.8% in men). CKD was present in 16.6% of the participants (men: 14% and women: 19.4%). The most prevalent component was abdominal obesity (63.6%), followed by low HDL cholesterol (36.7%), high triglyceride level (31.7%), hypertension (25.6%) and high fasting blood sugar (21.9%). Central obesity and low HDL level were observed to be more prevalent among women (P < 0.001). The presence of MetS was associated with CKD with an increased OR for CKD (OR: 3.07, 95% CI 2.09 - 4.50; P < 0.001). The adjusted ORs (95% CI) were 1.189 (0.554 - 2.555), 2.025 (0.990 - 4.141) and 4.769 (2.413 - 9.424) as the number of risk factors increased from 1 to ≥ 3. Individuals with hypertension and abdominal obesity had a higher OR of increased susceptibility to CKD in multivariate analysis. Conclusions: Our study indicated a strong association between CKD and MetS in the Iranian population. It is also suggested that individuals with metabolic risk factors should be detected earlier; they should also undergo multidisciplinary interventions to hinder worsening of the individual components of MetS and development of CKD. | en |
| DOI | https://doi.org/10.5812/ijem.81822 | en |
| Keyword | Metabolic Syndrome | en |
| Keyword | Chronic Kidney Disease | en |
| Keyword | Association | en |
| Publisher | Brieflands | en |
| Title | Relationships Between Various Components of Metabolic Syndrome and Chronic Kidney Disease in Shiraz, Iran | en |
| Type | Research Article | en |
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