Frequency of Connexin26 Gene Mutations in Autosomal Recessive Non-syndromic Deafness in Kermanshah(2002-4)

Abstract

Introduction: Hearing loss is the most common sensory defect in humans, affecting approximately 1 in 1000 neonates in which genetic factors are involved in more than 50%. Connexin 26 or GJB2 gene mutations are responsible for half of autosomal recessive non-syndromic hearing losses. The purpose of this study was to determine the GJB2 mutations frequency in autosomal recessive non-syndromic deafness in Kermanshah.