Avoiding Misdiagnosis Due to Antibody Interference with Serum Free Thyroxin
| Author | Pilar I Beato-Víbora | en |
| Author | S Alejo-González | en |
| Issued Date | 2017-01-31 | en |
| Abstract | Introduction: Interfering antibodies are capable of causing potentially misleading results in automated thyroid hormone immunoassays. Case Presentation: We report the case of a 46- year-old female patient with autoimmune hypothyroidism in chronic replacement treatment with levothyroxine who was presented 8 years after diagnosis with a thyroid function test showing an increased level of TSH and a very high level of FT4. Interference in the laboratory serum free thyroxin (FT4) test was suspected, due to the lack of symptoms of hyperthyroidism and a different immunoassay platform confirmed a low FT4 result. The discrepancy between the two results was explained by the presence of antiT4-autoantibodies. Conclusions: Antibody interference with serum free thyroxine must be considered when clinical findings and laboratory results show discrepancies. | en |
| DOI | https://doi.org/10.5812/ijem.37792 | en |
| Keyword | Free Thyroxine | en |
| Keyword | Antibody | en |
| Keyword | Immunoassay | en |
| Keyword | Interference | en |
| Publisher | Brieflands | en |
| Title | Avoiding Misdiagnosis Due to Antibody Interference with Serum Free Thyroxin | en |
| Type | Case Report | en |
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