Risk Factors of Parkinson’s Disease: A Case-Control Study in Moroccan Patients
| Author | Abderrahmane Achbani | en |
| Author | Abdellatif Ait Ougjij | en |
| Author | Sofiane Ait Wahmane | en |
| Author | Hasnaa Sine | en |
| Author | Ahmed Kharbach | en |
| Author | Youssef Bouchriti | en |
| Author | Ahmed Belmouden | en |
| Author | Mohamed Nejmeddine | en |
| Orcid | Abderrahmane Achbani [0000-0002-4262-2399] | en |
| Orcid | Abdellatif Ait Ougjij [0000-0002-0920-147X] | en |
| Orcid | Sofiane Ait Wahmane [0000-0003-2525-4851] | en |
| Orcid | Hasnaa Sine [0000-0002-3451-9738] | en |
| Orcid | Ahmed Kharbach [0000-0001-6536-5607] | en |
| Orcid | Youssef Bouchriti [0000-0002-8566-1451] | en |
| Orcid | Ahmed Belmouden [0000-0003-2553-8387] | en |
| Orcid | Mohamed Nejmeddine [0000-0003-0160-2727] | en |
| Issued Date | 2022-07-31 | en |
| Abstract | Background: Parkinson’s disease (PD) remains a significant health concern in Morocco. Multivariate analysis was not used in any study to evaluate the role of various factors that contributed to the onset of the disease. Objectives: This study investigates the role of family, environmental, and professional factors in PD development. Methods: The present study is an age-matched case-control study with risk estimation based on odds ratios (OR) with a 95% confidence interval (CI). In total, 180 cases were matched with 360 controls. Results: The average age of participants was 68.3 ± 11.2 years. Adjusted logistic regression analysis showed that the family history of PD (ORa = 7.19, CI 95% 3.41 - 15.13), male sex (ORa = 1.92, CI 95% 1.16 - 3.16), spring water consumption (ORa = 3.31, CI 95% 2.05 - 5.34), drug use (ORa = 2.12, CI 95% 1.33 - 3.38), a history of head injury (ORa = 3.38, CI 95% 1.16 - 9.83) and non - consumption of coffee (ORa = 3.04, CI 95% 1.56 - 5.90) were significantly associated with the onset of the disease. In a univariate analysis, well water consumption was observed as a significant risk factor but could not be shown to be significant in a multivariate analysis. Previous work on a farm (ORa = 0.30, CI 95% 0.16 - 0.54) and history of general anesthesia (ORa = 0.47, CI 95% 0.27 - 0.83) were inversely associated with PD risk. No statistical significance was observed in the data on occupational exposure and disease risk, although there was a 30% decrease in risk for the service occupations (ORa = 0.05, CI 95% 0.01 - 0.18). Conclusions: As a result, further research is needed to determine additional risk factors. | en |
| DOI | https://doi.org/10.5812/ans-126351 | en |
| Keyword | Parkinson’s Disease | en |
| Keyword | PD | en |
| Keyword | Risk Factors | en |
| Keyword | Conditional Logistic Regression | en |
| Keyword | Morocco | en |
| Publisher | Brieflands | en |
| Title | Risk Factors of Parkinson’s Disease: A Case-Control Study in Moroccan Patients | en |
| Type | Research Article | en |
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