The role of QX-314 and Capsaicin in producing long-lasting local anesthesia in the animal model of Trigeminal Neuralgia
| Author | Masoumeh Ezzati Givi |
| Author | Narges Ezzati Givi |
| Author | Hadi Imani Rastabi |
| Author | Farzin Memari |
| Issued Date | 2021-06-30 |
| Abstract | Introduction: Trigeminal Neuralgia (TN) consists of painful attacks often triggered with general activities, which cause impairment and disability.The first line of treatment consists of pharmacotherapy. However, the occurrence of many side-effects limits its application. Acute pain relief iscrucial for titrating oral drugs and making time for neurosurgical intervention. This study aimed to examine the long-term anesthetic effect of QX-314 and capsaicin in trigeminal neuralgia using an animal model.Materials and Methods: TN was stimulated by surgical constriction of the infraorbital nerve in rats. After seven days, anesthesia infiltrationwas done, and the duration of mechanical allodynia was compared. Thirty-five male Wistar rats were randomly divided into seven groups asfollows: control (normal saline); lidocaine (2%); QX314 (30 mM); lidocaine (2%)+QX314 (15 mM); lidocaine (2%)+QX314 (22 mM); lidocaine(2%)+QX314 (30 mM); and lidocaine (2%)+QX314 (30 mM) +capsaicin (1μg).Results: QX314 in combination with lidocaine significantly increased the duration of anesthesia, which was dose-dependent. The combination oflidocaine+QX314+capsaicin could significantly increase the duration of anesthesia in trigeminal neuralgia.Conclusion: In the present study, we demonstrated that the combination of QX-314 with lidocaine and capsaicin produced a long-lasting, reversiblelocal anesthesia and was superior to lidocaine alone in the fields of the duration of trigeminal neuropathic pain blockage. |
| DOI | https://doi.org/ |
| Keyword | Capsaicin |
| Keyword | Lidocaine |
| Keyword | Long-lasting |
| Keyword | Trigeminal neuralgia |
| Publisher | Brieflands |
| Title | The role of QX-314 and Capsaicin in producing long-lasting local anesthesia in the animal model of Trigeminal Neuralgia |
| Type | Research Article |
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