Evaluation of Predictive Risk Factors of Persistent Hypertension in Hyperaldosteronism After Surgery
| Author | Amal Ourdi | en |
| Author | Youssra Laalaoua | en |
| Author | Imane Assarrar | en |
| Author | Bouichrat Nisrine | en |
| Author | Siham Rouf | en |
| Author | Hanane Latrech | en |
| Orcid | Amal Ourdi [0009-0001-6921-1960] | en |
| Orcid | Siham Rouf [0000-0003-0624-6207] | en |
| Orcid | Hanane Latrech [0000-0001-9945-6857] | en |
| Issued Date | 2025-04-30 | en |
| Abstract | Background: Primary hyperaldosteronism (PHA) is a common cause of secondary arterial hypertension (AH), characterized by autonomous aldosterone secretion. It is frequently underdiagnosed and may persist even after surgical intervention. Objectives: The present study aimed to identify preoperative factors that could predict whether hypertension would persist or normalize following surgery and to outline relevant diagnostic characteristics. Methods: We conducted a descriptive, analytic, retrospective cohort study at a single center. The study included patients with PHA who were followed up at the Department of Endocrinology, Diabetology, and Nutrition in a hospital affiliated with Mohamed the First University of Oujda (CERBO), admitted between December 2014 and August 2023. Data were retrospectively collected from patient records over a 9-year period, involving 27 patients with PHA confirmed by an elevated aldosterone-to-renin ratio (ARR). Persistent disease was defined by persistent hypokalemia and hypertension (blood pressure > 140/90 mm Hg) after six months. Patients were divided into two groups: Those with complete resolution of hypertension (group A) and those with persistent hypertension (group B). Data were analyzed using SPSS version 21. Results: The mean age of patients was 48.47 ± 10.87 years, with a female predominance (66.7%). The etiological assessment identified Conn’s adenoma in 70.4% (n = 19) of cases and bilateral adrenal hyperplasia in 29.6% (n = 8). Surgery was performed in 51.9% (n = 14) of cases, with 50% (n = 7) maintaining persistent hypertension post-surgery, while 28.6% (n = 4) showed a reduction in antihypertensive medications. Two predictive factors for persistent hypertension were identified: Age > 50 years and hypertension duration > 5 years. Predictive factors for normalization of hypertension post-surgery included systolic blood pressure (SBP) < 140 mm Hg, diastolic blood pressure (DBP) < 90 mm Hg, glomerular filtration rate (GFR) > 90 mL/min/1.75 m2, and a low incidence of diabetes and dyslipidemia. Conclusions: This study demonstrates that PHA can lead to resistant hypertension, highlighting the necessity for further research in this area. | en |
| DOI | https://doi.org/10.5812/ijem-156728 | en |
| URI | https://brieflands.com/journals/ijem/articles/156728 | en |
| Keyword | Primary Hyperaldosteronism | en |
| Keyword | Endocrine Hypertension | en |
| Keyword | Conn’s Adenoma | en |
| Keyword | Adrenal Gland | en |
| Keyword | Persistent Hypertension | en |
| Keyword | Predictive Factors | en |
| Publisher | Brieflands | en |
| Title | Evaluation of Predictive Risk Factors of Persistent Hypertension in Hyperaldosteronism After Surgery | en |
| Type | Research Article | en |
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