Spreading of Extended-Spectrum Beta-Lactamases Among the <i>Klebsiella pneumoniae</i> Strains Isolated from Outpatients With Urinary Tract Infection in Zahedan, Southeast Iran

Abstract

Background: Extended-spectrum beta-lactamases (ESBLs) represents a significant and rapid emerging problem around the world. Nowadays, antibiotic resistance determinants are prevalent in both hospital and community strains of Gram-negative enteric bacteria. Materials and Methods: In this sectional-descriptive study, 87 clinical isolates of Klebsiella pneumoniae were collected from outpatients and their susceptibility to antimicrobial agents, minimum inhibitory concentration (MIC) values for third-generation cephalosporins and ESBLs production were assessed. Results: Of 87 K. pneumoniae clinical isolates, 20 (22.9%) isolates represented the ESBLs phenotype. Conclusions: Our results demonstrated that the resistance to the third-generation cephalosporins in K. pneumoniae strains isolated from outpatients is relatively high in Zahedan.