Analysis of Vascular Endothelial Growth Factors -634C/G and +936C/T Polymorphisms and Their Serum Levels in Women Suffering from Preeclampsia
| Author | Hojjat Hosseini | en |
| Author | Ata A Ghadiri | en |
| Author | Abdolah Mousavi Salehi | en |
| Author | Saber Rokhafrooz | en |
| Author | Mahin Najafian | en |
| Author | Mehri Ghafourian | en |
| Orcid | Abdolah Mousavi Salehi [0000-0003-1116-9760] | en |
| Orcid | Mahin Najafian [0000-0002-6649-3931] | en |
| Orcid | Mehri Ghafourian [0000-0003-0140-7083] | en |
| Issued Date | 2024-03-31 | en |
| Abstract | Background: Preeclampsia (PE) is a pregnancy-related syndrome characterized by hypertension and proteinuria, affecting approximately 6-8% of pregnancies and contributing to about 40% of premature births. Objectives: This study aimed to explore the polymorphisms -634C/G and +936C/T in the VEGF gene and their association with serum VEGF levels in pregnant women with PE. Methods: In this case-control study, peripheral blood samples were collected from 135 women with PE and 135 normal pregnant women as the control group. DNA extraction was performed using the phenol-chloroform method. The VEGF gene polymorphisms were detected using the PCR-RFLP method using specific primers. Additionally, serum VEGF concentrations were measured using the ELISA method. Results: Maternal age, gestational week, maternal hemoglobin, and BMI were significantly correlated with the likelihood of developing PE, whereas the season of occurrence was not found to be a significant factor. No significant difference was observed in the -634C/G and +936C/T polymorphisms of the VEGF gene between the two groups. Moreover, serum VEGF levels in PE patients were significantly higher than in the control group (P < 0.001). Conclusions: Although serum VEGF concentrations were significantly elevated in women with PE, the -634C/G and +936C/T polymorphisms of the VEGF gene do not appear to be associated with the onset of PE. Further research is necessary to fully elucidate the risk factors of PE syndrome. | en |
| DOI | https://doi.org/10.5812/jjcmb-143749 | en |
| Keyword | Preeclampsia | en |
| Keyword | Single Nucleotide Polymorphisms | en |
| Keyword | VEGF | en |
| Publisher | Brieflands | en |
| Title | Analysis of Vascular Endothelial Growth Factors -634C/G and +936C/T Polymorphisms and Their Serum Levels in Women Suffering from Preeclampsia | en |
| Type | Research Article | en |
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