Comparison of the Effects of Dexmedetomidine and Remifentanil on Cognition State After Cataract Surgery
| Author | Mahtab Poorzamany Nejat Kermany | en |
| Author | Mastaneh Dahi | en |
| Author | Reyhaneh Yamini Sharif | en |
| Author | Badiozaman Radpay | en |
| Issued Date | 2016-06-01 | en |
| Abstract | Background: Dexmedetomidine is a potent and highly specific α2-adrenoreceptor agonist that induces sedative and analgesic effects over a short-term period. As a result of these benefits, dexmedetomidine may be a better alternative than other available drugs for keeping the patient’s cognition state in an acceptable condition after outpatient ophthalmic surgeries. Objectives: This randomized study was conducted to compare the sedative effects of dexmedetomidine and remifentanil on the cognitive state of patients who have undergone cataract surgery. Patients and Methods: A total of 100 patients who were candidates for cataract surgery under local anesthesia received either dexmedetomidine (50 patients; D group) or remifentanil (50 patients; R group) in a double-blind, randomized study. The baseline cardiovascular status and mini mental state examination (MMSE) score for each patient were recorded. As a loading dose, dexmedetomidine (0.5 µg/kg) and remifentanil (0.1 µg/kg) were infused at 10 minutes and 5 minutes before topical anesthesia, respectively. Subsequently, the maintenance dose was administered at 0.2 µg/kg/hour and 0.05 µg/kg/minutes in the D and R groups, respectively. The surgical procedure was begun when the bispectral index (BIS) reached 70 - 80. MMSE test was done at a postanesthetic care unit (PACU) 120 minutes after the discontinuation of the drug. Results: There was no statistically significant difference between the MMSE scores of the two groups before surgery (P = 0.6), but the MMSE test conducted at the PACU revealed significantly better cognitive outcomes in the D group than in the R group in patients younger and older than 65 years (P = 0.03 and P = 0.0001, respectively). Conclusions: This study revealed that dexmedetomidine may be a suitable agent for sedation in cataract surgery because it results in a more favorable postoperative cognitive status than remifentanil. Likewise, dexmedetomidine had no significant adverse effects on cardiovascular or respiratory systems. | en |
| DOI | https://doi.org/10.5812/aapm.33448 | en |
| Keyword | Cognitive Disorder | en |
| Keyword | Sedative Drug | en |
| Keyword | Cataract Surgery | en |
| Publisher | Brieflands | en |
| Title | Comparison of the Effects of Dexmedetomidine and Remifentanil on Cognition State After Cataract Surgery | en |
| Type | Research Article | en |
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