Investigating the Role of Tumor-Associated Macrophages in the Resistance of Brain Metastatic Tumor Cells to Paclitaxel in Two- Dimensional and Three-Dimensional Cell Culture Conditions

Abstract

Background: Brain metastasis is a devastating complication in breast cancer patients. Tumor-associated macrophages (TAMs) are cells in innate immunity, repair, and homeostasis. These cells play an important role in drug resistance in the metastatic microenvironment.