The Role of Autophagy in Respiratory Complications of COVID-19
| Author | Shima Fakher | en |
| Author | Payam Peymani | en |
| Author | Saeid Ghavami | en |
| Author | Pooneh Mokarram | en |
| Orcid | Shima Fakher [0000-0002-5764-3651] | en |
| Orcid | Saeid Ghavami [0000-0001-5948-508X] | en |
| Orcid | Pooneh Mokarram [0000-0002-9717-0473] | en |
| Issued Date | 2020-04-08 | en |
| Abstract | Background: The rapid spreading of corona virus disease 2019 (COVID-19) worldwide results in pneumonia and acute respiratory distress syndrome in many patients, which can be the major cause of death in cases with COVID-19. It has been reported that chloroquine (CQ) has improved COVID-19-induced pneumonia in clinical trials. Objectives: Since CQ and its derivatives are proved to exhibit anti-autophagy properties based on previous studies, autophagy can be introduced as a possible mechanism of respiratory complications. Methods: In the current study, we reviewed papers of Google Scholar database with no time limitation. Results: It was revealed that autophagy has an important role in the manifestation of COVID-19 respiratory complications Conclusions: Autophagy is triggered by SARS-CoV2 virus for its replication and autophagy inhibitory treatments might be considered promising therapeutics. | en |
| DOI | https://doi.org/10.5812/semj.102967 | en |
| Keyword | COVID-19, Autophagy | en |
| Keyword | Chloroquine | en |
| Keyword | Pneumonia | en |
| Keyword | Therapeutics | en |
| Publisher | Brieflands | en |
| Title | The Role of Autophagy in Respiratory Complications of COVID-19 | en |
| Type | Brief Report | en |
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