Acromegaly Associated with Leukemia: A Case Report
| Author | MH Adib | en |
| Author | A Ebadi | en |
| Issued Date | 2009-01-31 | en |
| Abstract | Acromegaly is one of the most common clinical presentations of pituitary tu-mors. Some patients with this condi-tion may be affected by other benign or malignant neoplasms. There are a few reports of acromegaly in association with acute leukemias.Case report: Reported here is a case of acromega-ly associated with Philadelphia positive acute lymphoblastic leukemial. The patient was a 61 year-old man, evaluated for complaints of bleed-ing from pilonidal cyst and weakness. He had typical acromegalic features. Laboratory tests showed he had pancytopernia and elevated IGF-1 levels. Imaging studies revealed he had a pitui-tary macroadenoma. The result of aspiration and biopsy of bone marrow and flowcytometric analysis confirmed the diagnosis of acute lym-phoblastic leukemia, Pre B cell type. Cytogenetic study of lymphoblasts revealed translocation of the 9 and 22 or Philadelphia chromosome.Conclusion: It is suggested that the proliferative effect of growth hormone, as well as its anti-apoptotic activity related to IGF-1 may result in the increased incidence of neoplastic processes including acute leukemias in this group of pa-tients. | en |
| DOI | https://doi.org/ | en |
| URI | https://brieflands.com/journals/ijem/articles/74899 | en |
| Keyword | Acromegaly | en |
| Keyword | Acute lymphoblastic leukemia | en |
| Keyword | Philadelphia chromosome | en |
| Publisher | Brieflands | en |
| Title | Acromegaly Associated with Leukemia: A Case Report | en |
| Type | Case Report | en |
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