The Effects of Prenatal Norharman Exposure on Seizure Severity in Rats
| Author | mohammad sofiabadi | en |
| Issued Date | 2021-06-30 | en |
| Abstract | Background: Norhraman is an alkaloid that can damage the nervous system. Objective: This experimental study aimed to investigate the effects of prenatal norharman exposure on seizure severity in adult rats. Methods: A total of 36 Wistar rats were randomly divided into 3 groups as follows: Control, sham (solvent), and norharman (1000 ug/kg). The sham and norharman groups were treated once daily for 8-18 of the fetal period. 2 months after birth, kindling was performed by the daily injection of Pentylenetetrazol (PTZ) (30 mg/kg); then, the seizure behavior was recorded for approximately 30 minutes. The obtained data were analyzed using Analysis of Variance (ANOVA) and Tukey’s posthoc test. Results: The present study data indicated that administrating norharman in the fetal period increased seizure responses to PTZ, i.e., significant in the examined female rats (P | en |
| DOI | https://doi.org/ | en |
| Keyword | Norharman | en |
| Keyword | Seizure | en |
| Keyword | Pentylenetetrazol | en |
| Keyword | Rat | en |
| Publisher | Brieflands | en |
| Title | The Effects of Prenatal Norharman Exposure on Seizure Severity in Rats | en |
| Type | issue_documents_importer | en |
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