Lower Extremity Arterial Calcification as a Predictor of Coronary Atherosclerosis in Patients with Peripheral Arterial Disease
| Author | Hwa Seon Shin | en |
| Author | Mi Jung Park | en |
| Author | Kyung Nyeo Jeon | en |
| Author | Jae Min Cho | en |
| Author | Kyung Soo Bae | en |
| Author | Dae Seob Choi | en |
| Author | Jae Boem Na | en |
| Author | Ho Cheol Choi | en |
| Author | Hye Young Choi | en |
| Author | Ji Eun Kim | en |
| Author | Soo Bueum Cho | en |
| Author | Sung Eun Park | en |
| Issued Date | 2016-04-01 | en |
| Abstract | Background: Until now, there has been no study on the relationship between the calcification of the lower extremity arteries and significant coronary arterial disease (CAD). Objectives: To evaluate whether lower extremity calcium scores (LECS) are associated with CAD and whether this can predict multivessel-CAD in patients with peripheral arterial disease (PAD). Patients and Methods: We retrospectively enrolled 103 PAD patients without cardiac symptoms or known CAD. All patients underwent cardiac computed tomography (CT) and lower extremity CT within 1 month and were categorized as nonsignificant CAD, single-CAD, or multivessel-CAD. The coronary calcium scores (CCS) were quantitatively measured according to the Agatston method and LECS were semi-quantitatively measured according to the presence of lower extremity calcification in the segment. The extent of CAD was evaluated according to the presence of ≥ 50% luminal diameter stenosis in the segment of CAD. Results: LECS in multivessel-CAD were significantly higher than those in nonsignificant CAD (10.0 ± 5.8 versus 4.0 ± 3.1, P < 0.001). LECS significantly correlated with CCS (r = 0.831, P < 0.001) and the extent of CAD (r = 0.631, P < 0.001). Multivariate regression analysis demonstrated LECS and log-transformed CCS were independent predictors for multivessel-CAD. In receiver operating characteristic curve analysis, the diagnostic performance of LECS was 0.807 (95% confidence interval = 0.724-0.891, P < 0.001) for predicting multivessel-CAD. Conclusion: Peripheral arterial calcification is significantly correlated with CAD extent in patients with PAD. Peripheral arterial calcification can be a useful marker for predicting multivessel-CAD. | en |
| DOI | https://doi.org/10.5812/iranjradiol.33179 | en |
| Keyword | Atherosclerosis | en |
| Keyword | Coronary Artery Disease | en |
| Keyword | Multidetector Computed Tomography | en |
| Keyword | Peripheral Arterial Disease | en |
| Keyword | Vascular Calcification | en |
| Publisher | Brieflands | en |
| Title | Lower Extremity Arterial Calcification as a Predictor of Coronary Atherosclerosis in Patients with Peripheral Arterial Disease | en |
| Type | Research Article | en |