Association Between Pre-Transplant Magnesemia and Post-Transplant Dysglycemia in Kidney Transplant Recipients
| Author | Azam Alamdari | en |
| Author | Ghazal Asadi | en |
| Author | Farzaneh Sadat Minoo | en |
| Author | Mohammad-Reza Khatami | en |
| Author | Seyed Mansour Gatmiri | en |
| Author | Simin Dashti-Khavidaki | en |
| Author | Saba Heydari Seradj | en |
| Author | Neda Naderi | en |
| Orcid | Azam Alamdari [0000-0002-5319-8183] | en |
| Orcid | Neda Naderi [0000-0002-9117-9610] | en |
| Issued Date | 2020-01-14 | en |
| Abstract | Background: Serum magnesium (Mg) status in kidney transplant recipients has been a center of attention in the past few years. Current evidence suggests an association between pre-transplant hypomagnesemia and post-transplant hyperglycemia. Objective: The purpose of this study was to assess the associations of pre-transplant magnesemia with blood glucose disturbances within 6 months post-kidney transplantation. Methods: In this retrospective cohort, 89 first-time kidney transplant recipients with 6 months of follow-up were included. None of the participants had a positive history of rejection, pre-transplant history of diabetes mellitus or fasting plasma glucose ≥ 100 mg/dL. Results: Post-transplant diabetes mellitus (PTDM) and impaired fasting glucose (IFG) 6 months post-transplant was found in 7.9% and 41.6% of the study group, respectively. The mean pre-transplant serum Mg level was 1.92 ± 0.30 mg/dL in the study population (n = 89), and it was significantly lower in IFG (n = 37) and IFG/PTDM (n = 44) groups compared to normoglycemic (n = 45) recipients (1.83 ± 0.31 mg/dL vs. 2.00 ± 0.27 mg/dL, P = 0.008, and 1.84 ± 0.31 mg/dL vs. 2.00 ± 0.27 mg/dL, P = 0.012, respectively). Patients with serum Mg less than 1.9 mg/dL were nearly 2.6 times more likely to develop IFG or IFG/PTDM within 6 months post-transplant (P = 0.044 and P = 0.040, respectively). Conclusions: Pre-transplant hypomagnesemia may be considered a risk factor for developing post-transplant glycemic disturbances, and patients with lower pre-transplant Mg concentration could be at a higher risk for developing IFG. | en |
| DOI | https://doi.org/10.5812/ijem.97292 | en |
| Keyword | Kidney Transplantation | en |
| Keyword | Serum Magnesium | en |
| Keyword | Impaired Fasting Glucose | en |
| Publisher | Brieflands | en |
| Title | Association Between Pre-Transplant Magnesemia and Post-Transplant Dysglycemia in Kidney Transplant Recipients | en |
| Type | Research Article | en |
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