Vitamin E Supplementation Reduces Oxidative Stress in the Male Wistar Rats’ Brain Against Polyvinyl Chloride Products

Abstract

Background: Polyvinyl chloride (PVC) exerts toxic effects via the formation of oxidative stress on the brain. Antioxidants such as Vitamin E (Vit E) can affect free radicals. Objectives: This study was conducted to decrease damage and oxidative stress against PVC products in rats’ brain by vitamin E. Methods: In the current study, we used 24 male Wistar rats in four groups (N = 6 rats per group) as the control, Vit E, PVC, PVC plus Vit E. We orally administered vitamin E and PVC for 40 days. Then the rats were anesthetized and the brain was removed and transferred to a temperature of -70ºC in order to measure lipid peroxidation. Results: our results revealed that oral administration of PVC decreased catalase and total antioxidant capacity levels, and increased malondialdehyde in PVC exposed rats. Vitamin E improved spatial memories by enhancing neurogenesis in the brain. Conclusions: Exposure to PVC can produce oxidative stress enzymes and make brain damage. Vitamin E, as an antioxidant, can decrease the toxic effects of PVC and protect the brain.