Vitamin E Supplementation Reduces Oxidative Stress in the Male Wistar Rats’ Brain Against Polyvinyl Chloride Products
| Author | Abbas Sadeghi | en |
| Author | Laya Ghahari | en |
| Author | Mitra Yousefpour | en |
| Orcid | Mitra Yousefpour [0000-0002-9670-2685] | en |
| Issued Date | 2019-06-01 | en |
| Abstract | Background: Polyvinyl chloride (PVC) exerts toxic effects via the formation of oxidative stress on the brain. Antioxidants such as Vitamin E (Vit E) can affect free radicals. Objectives: This study was conducted to decrease damage and oxidative stress against PVC products in rats’ brain by vitamin E. Methods: In the current study, we used 24 male Wistar rats in four groups (N = 6 rats per group) as the control, Vit E, PVC, PVC plus Vit E. We orally administered vitamin E and PVC for 40 days. Then the rats were anesthetized and the brain was removed and transferred to a temperature of -70ºC in order to measure lipid peroxidation. Results: our results revealed that oral administration of PVC decreased catalase and total antioxidant capacity levels, and increased malondialdehyde in PVC exposed rats. Vitamin E improved spatial memories by enhancing neurogenesis in the brain. Conclusions: Exposure to PVC can produce oxidative stress enzymes and make brain damage. Vitamin E, as an antioxidant, can decrease the toxic effects of PVC and protect the brain. | en |
| DOI | https://doi.org/10.5812/amh.92768 | en |
| Keyword | Oxidative Stress | en |
| Keyword | Polyvinyl Chloride | en |
| Keyword | Vitamin E | en |
| Keyword | Brain | en |
| Keyword | Rat | en |
| Publisher | Brieflands | en |
| Title | Vitamin E Supplementation Reduces Oxidative Stress in the Male Wistar Rats’ Brain Against Polyvinyl Chloride Products | en |
| Type | Research Article | en |
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