Modulating Effects of Aerobic Exercise on Apoptosis Markers in Cardiac Cells of Diabetic Rats With Morphine Deprivation Syndrome

Abstract

Background: Diabetes and morphine play important role in cardiac apoptosis. Objective: The purpose of this study is to investigate the effect of eight weeks of aerobic training on apoptosis indices in the heart tissue of diabetic rats with morphine withdrawal syndrome. Methods: In this study, 32 male Wistar rats were randomly divided into four groups: diabetic control, diabetic control+morphine withdrawal syndrome, diabetic+aerobic exercise, and diabetic+morphine withdrawal syndrome+aerobic exercise. Then the induction of diabetes and morphine was done. The training groups participated in an increasing treadmill running program for 8 weeks (three sessions per week). 24 h after the last training session, heart tissue was sampled. The levels of Bcl2-associated X (Bax) and B-cell lymphoma protein 2 (Bcl-2) proteins in the tissue of the left ventricle of the rat heart were measured by the ELISA method. Data analysis was performed with one-way analysis of variance and Tukey's post hoc test at a significance level of p