Trans-Catheter Aortic Valve Replacement (AVR) in Severe Aortic Stenosis: A 3-year Experience in Modarres Hospital (A Tertiary University Hospital, Tehran, Iran)
| Author | Mohammad Hassan Namazi | en |
| Author | Saeed Alipour-Parsa | en |
| Author | Mohammad Khani | en |
| Author | Vahid Eslami | en |
| Author | Morteza Safi | en |
| Author | Hossein Vakili | en |
| Author | Habibollah Saadat | en |
| Author | Ramin Baghaei Tehrani | en |
| Author | Manouchehr Hekmat | en |
| Author | Ali Dabbagh | en |
| Author | Mahmood Beheshti Monfared | en |
| Author | Hamid Reza Pouraliakbar | en |
| Author | Isa Khaheshi | en |
| Author | Nasim Sohrabifar | en |
| Orcid | Vahid Eslami [0000-0002-4304-3997] | en |
| Orcid | Habibollah Saadat [0000-0001-6459-3317] | en |
| Orcid | Ali Dabbagh [0000-0003-4344-8131] | en |
| Orcid | Hamid Reza Pouraliakbar [0000-0002-2557-4030] | en |
| Orcid | Isa Khaheshi [0000-0001-6694-6542] | en |
| Orcid | Nasim Sohrabifar [0000-0001-8512-1757] | en |
| Issued Date | 2025-12-31 | en |
| Abstract | Background: Aortic stenosis (AS) is a progressive disease with high mortality if untreated; however, many high-risk patients do not receive surgical aortic valve replacement (AVR) due to comorbidities. Transcatheter aortic valve implantation (TAVI) offers a less invasive therapeutic choice. Objectives: This study evaluated the outcomes of TAVI at the Shahid Modarres Educational and Therapeutic Center in Iran. Methods: In this cross-sectional study, 100 consecutive patients (77.82 ± 6.97 years) with severe symptomatic AS underwent TAVI using balloon-expandable valves under conscious sedation over 3 years. Pre-procedural assessments included echocardiography and computed tomography (CT) angiography. The procedure was performed via transfemoral access under fluoroscopic guidance. Outcomes assessed included procedural complications, mortality at 30 days and 6 months, and echocardiographic data pre- and post-procedure. Results: The TAVI was successful in 99% of patients. Procedural complications occurred in 12%, with a mortality rate of 1%. Post-procedure, the mean pressure gradient (MPG) was 9.75 ± 6.19 mmHg and the peak pressure gradient (PPG) was 19.25 ± 10.15 mmHg. Mortality at 30 days was 3%, increasing to 6% by 6 months, while 23% were hospitalized for any cause within 6 months. Notable correlations were found between gradient improvement (ΔMPG and ΔPPG) and factors such as aortic valve area (AVA) and left ventricular ejection fraction (LVEF). Conclusions: Initial experiences with TAVI at our center indicate it is a safe and effective treatment for high-risk patients with severe AS, with positive mid-term outcomes underscoring the need for careful patient selection and management. | en |
| DOI | https://doi.org/10.5812/icrj-161526 | en |
| Keyword | Aortic Stenosis | en |
| Keyword | TAVI | en |
| Keyword | Procedural Outcomes | en |
| Keyword | Mortality | en |
| Keyword | Echocardiography | en |
| Publisher | Brieflands | en |
| Title | Trans-Catheter Aortic Valve Replacement (AVR) in Severe Aortic Stenosis: A 3-year Experience in Modarres Hospital (A Tertiary University Hospital, Tehran, Iran) | en |
| Type | Research Article | en |
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