Strategies of Starting and Stopping Antiepileptic Drugs in Patients With Seizure or Epilepsy; A Comprehensive Review
| Author | Majid Ghaffarpour | en |
| Author | Hossein Ali Ghelichnia | en |
| Author | Mohammad Hossein Harrichian | en |
| Author | Mojdeh Ghabaee | en |
| Author | Mohammad Mahdi Saber Tehrani | en |
| Author | Parviz Bahrami | en |
| Issued Date | 2014-10-01 | en |
| Abstract | Context: Seizure is a transient neurologic dysfunction caused by sudden abnormal firing of cerebral neurons. Epileptic syndrome is a complex of symptoms and signs that is characterized by not only the etiology but also the age at onset, seizure type, pattern of electroencephalography and prognosis. Evidence Acquisition: Treatment of the first seizures depends on their nature; some of them need no antiepileptic drugs (AED) therapy whereas the others should be treated appropriately. AEDs have long- and short-term adverse effects, interaction with other medications, and occupational and/or psychological consequences. Therefore, discontinuation of AEDs should be considered after a free-seizure period. Results: Studies show that the rate of seizure recurrence after AEDs withdrawal is about two to three times more than those who continue therapy; thus, the most difficult decision facing a neurologist is when to start medication and when/how it should be discontinued. Conclusions: This review explores the literature to answer above questions. | en |
| DOI | https://doi.org/10.5812/archneurosci.14182 | en |
| Keyword | Seizures | en |
| Keyword | Epilepsy | en |
| Keyword | Anticonvulsants | en |
| Publisher | Brieflands | en |
| Title | Strategies of Starting and Stopping Antiepileptic Drugs in Patients With Seizure or Epilepsy; A Comprehensive Review | en |
| Type | Review Article | en |
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