Human Embryo Genetic Manipulation from the Point of View of Bioethics and Human Rights
| Author | Maryam Afshari | en |
| Author | Zamaneh Shahini | en |
| Author | Mohammad Kordkatouli | en |
| Orcid | Maryam Afshari [0000-0003-1861-2542] | en |
| Orcid | Zamaneh Shahini [0009-0003-4537-5279] | en |
| Orcid | Mohammad Kordkatouli [0009-0006-3008-6820] | en |
| Issued Date | 2025-07-31 | en |
| Abstract | Background: Advancements in human embryo genetic manipulation, including eugenics and modern gene-editing technologies such as CRISPR-Cas9, have created new possibilities for preventing hereditary diseases and improving human health. These technologies enable targeted correction of genetic defects and contribute to understanding complex reproductive and developmental processes. However, they also raise profound ethical, social, and human rights concerns, such as genetic discrimination, violation of human dignity, and unpredictable genomic consequences. Bioethical principles and international human rights instruments provide essential frameworks to ensure the responsible and equitable use of such innovations. Objectives: This study examines human embryo genetic manipulation from the perspective of bioethics and human rights, identifying its scientific advantages, potential risks, and moral implications. The aim is to explore how technological progress can coexist with respect for fundamental human values, including dignity, equality, and integrity. Methods: Using a descriptive-analytical and applied research approach, this study reviews key literature on gene editing, preimplantation genetic diagnosis (PGD), and relevant international conventions — including UNESCO’s Universal Declaration on the Human Genome and Human Rights and the Oviedo Convention. Ethical, legal, and social aspects are comparatively analyzed to assess the boundaries of responsible scientific practice. Results: Findings indicate that while genetic manipulation can improve diagnosis, prevent hereditary diseases, and enhance quality of life, it also poses risks of genetic discrimination, unequal access, social exclusion, and violation of human rights. Ethical debates emphasize balancing scientific advancement with the preservation of human dignity and justice. Conclusions: Human embryo genetic manipulation represents a transformative yet ethically sensitive frontier in medicine. Its responsible application requires strict ethical oversight, legal regulation, public awareness, and international cooperation. Ensuring that such interventions respect human dignity, equality, and fundamental rights is vital for achieving sustainable scientific progress that benefits both present and future generations. | en |
| DOI | https://doi.org/10.5812/gct-166959 | en |
| URI | https://brieflands.com/journals/gct/articles/166959 | en |
| Keyword | Biological Ethics | en |
| Keyword | Genetics | en |
| Keyword | Human Fetus | en |
| Keyword | Human Rights | en |
| Publisher | Brieflands | en |
| Title | Human Embryo Genetic Manipulation from the Point of View of Bioethics and Human Rights | en |
| Type | Research Article | en |
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