Adverse Events and Side Effects of Chimeric Antigen Receptor (CAR) T Cell Therapy in Patients with Hematologic Malignancies
| Author | Pooria Safarzadeh Kozani | en |
| Author | Shima Shabani | en |
| Orcid | Pooria Safarzadeh Kozani [0000-0002-9901-7851] | en |
| Issued Date | 2021-02-28 | en |
| Abstract | Chimeric antigen receptor (CAR) T cell therapy is rapidly being established as a new cancer treatment modality especially for the treatment of hematologic malignancies. Alongside being capable of inducing durable responses in such malignancies, CAR T cell therapy has always been accompanied by exclusive toxicities such as cytokine release syndrome (CRS), that can range from mild to life-threatening. These toxicities require intensive monitoring and fast and executive management procedures to reduce the level of damages or the rate of mortality in CAR T cell therapy recipients. In this review, we tend to introduced some of the most common CAR T cell therapy-related toxicities and their clinical demonstrations. Furthermore, we also introduce some of the management procedures commonly considered in this regard. | en |
| DOI | https://doi.org/10.5812/tms.116301 | en |
| Keyword | Chimeric Antigen Receptor | en |
| Keyword | Cancer Immunotherapy | en |
| Keyword | Toxicities | en |
| Keyword | Clinical Management | en |
| Keyword | Cytokine Release Syndrome | en |
| Publisher | Brieflands | en |
| Title | Adverse Events and Side Effects of Chimeric Antigen Receptor (CAR) T Cell Therapy in Patients with Hematologic Malignancies | en |
| Type | Review Article | en |
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