Antibiotic Resistance Pattern of Extended-Spectrum Beta-Lactamases-Producing <i>Klebsiella pneumoniae</i> Clinical Isolates from Zahedan, Southeast Iran

Abstract

Background: Resistance to various classes of antibiotics is common among extended-spectrum beta-lactamases (ESBLs)-producing bacteria. Objectives: To determine the antibiotic resistance pattern of ESBLs-producing K. pneumoniae clinical isolates from Zahedan. Methods: In this sectional-descriptive study, susceptibility of 51 ESBLs-producing K. pneumoniae isolates to 18 antimicrobial agents was determined. Results: All isolates were resistant to cefotaxime, cefpodoxime and amoxicillin as well as susceptible to colistin sulfate. Also, most isolates were resistant to trimethoprim/sulfamethoxazole and aztreonam. Conclusions: Our findings demonstrated that the rate of resistance to beta-lactams, sulfonamides, tetracyclines, aminoglycosides and fluoroquinolones in ESBLs-producing K. pneumoniae isolates is high in Zahedan.